Your old teeth might be the secret to regrowing your jawbone by tricking your body into 'healing mode.'
Instead of using synthetic materials, doctors found that using a patient's own ground-up teeth works as a superior bone graft. The material sends a signal to immune cells that recruits stem cells to the site, turning what was once medical waste into a high-tech tool for regeneration.
Dentin Graft Mediates Functional Bone Regeneration through macrophage immunomodulation-induced BMSC-recruitment via SPP1/CD44 Axis
SSRN · 6469190
Autogenous dentin bone graft materials (ADGM) represent a unique class of bioactive material for bone repair, but their functional mechanism remains elusive. This work demonstrates that a chairside-prepared ADGM directly addresses the clinical shortcomings of commercial grafts by biodegrading in harmony with new bone formation and providing potent osteoinductive signals. We combine retrospective clinical evidence, showing significantly enhanced bone density in patients, with preclinical rodent m