We built a dialysis filter that 'thinks' for itself, automatically balancing a patient’s blood sugar while it cleans their blood.
Instead of a passive mesh, this membrane changes its pore size based on the amount of glucose it detects. It prevents patients from losing too much sugar during treatment while clearing out excess sugar when levels are too high.
Charge Triggered Glucose Buffering in the Gel-Embedded Hemodialysis Membranes for Autonomous Glycemic Homeostasis Regulation
SSRN · 6556648
Achieving autonomous regulation of blood glucose homeostasis during hemodialysis is critical for mitigating systemic complications, while current membranes lack the capacity for dynamic response to fluctuating glucose levels. This work reports a smart, gel-embedded membrane fabricated via an in-situ copolymerization strategy to provide a glucose-responsive system. By incorporating a semi-interpenetrating phenylboronic acid/quaternary ammonium gel network within a rigid polyethersulfone skeleton,