AI & ML Collision

Scientists managed to take a 'lesson' learned by one batch of brain cells and literally stitch it into a completely different group of cells.

April 6, 2026

Original Paper

Computing with Living Neurons: Chaos-Controlled Reservoir Computing with Knowledge Transplant

Seung Hyun Kim, Zhi Dou, Gaurav Upadhyay, Anay Pattanaik, Leo Maslov, Lav Varshney, John Beggs, Howard Gritton, Mattia Gazzola

arXiv · 2604.02552

AI-generated illustration

The Takeaway

This treats biological neural networks as reusable, modular computing hardware that can be stabilized and programmed. It represents a significant step toward hybrid 'wetware' computers that merge biology with traditional algorithms.

From the abstract

We introduce chaos-controlled Reservoir Computing (cc-RC) for living neural cultures: dynamically rich substrates of unique potential for adaptive computation. To account for intrinsic biological variability, cc-RC combines: (i) pre-training identification of each culture's dynamical signature and phase-portrait attractor; (ii) low-power optical chaos control to stabilize spontaneous and stimulus-evoked activity; (iii) readout training within this controlled regime. Across hundreds of neural sam